computational microscopy
Our research
We develop computational microscopy technologies for scalable analysis of biological systems. Our research jointly optimizes the optical design and inverse algorithms to reveal physical properties of living systems with increasing precision, resolution, and throughput. We develop machine learning approaches to gain biological insights from this rich data.
Our technologies are designed to be effective across scales of organelles, cells, organoids, and tissues. We pursue discovery of biological mechanisms and therapeutic opportunities in collaboration with Chan Zuckerberg Biohub’s initiatives, platforms, and university partners. Our interdisciplinary research spans fields of optics, inverse algorithms, machine learning, and biophysics.
Our current technological research is focused on:
- Label-free imaging of density and order across biological scales
- Measurement of nanoscale order among molecules.
- Inverse algorithms for vectorial imaging
- Machine learning algorithms to transform voxels into measurements
We pursue collaborative biological research in:
- Mapping myelination, cell types, and connectivity in brain tissue.
- Analyzing lifecycle and biogenesis of viruses in host cells to discover new therapeutic opportunities.
- Understanding architectural basis of organelle function.
The lab
Shalin Mehta, Ph.D.
Platform Leader
Postdoc: Human Frontier Science Program Fellow, Marine Biological Laboratory, Woods Hole
PhD: Optics, National University of Singapore
Syuan-Ming Guo, Ph.D.
R&D Engineer
PhD & Postdoc: MIT, focusing on physical chemistry and data analysis.
Ivan Ivanov, Ph.D.
R&D Engineer
PhD: Stanford University, focusing on single-molecule biophysics.
Li-Hao Yeh, Ph.D.
R&D Engineer
PhD: University of California Berkeley, focusing on computational optics
Bryant Chhun, M.S.
R&D Engineer
Imaging Scientist: Singular Bio
MS: UCSF, focusing on super-resolution microscopy.
Publications
News
Past members
Lienna Chan, Intern, UC Berkeley
Medha Somayaji, Intern, UC Berkeley
Andrew Chen, Intern, UC Berkeley
Michael Wu, Intern, Stanford
Jaehee Park, Contract R&D Engineer, now at Ramona Optics
Elliot Mount, R&D Engineer, now at System1 Bioscience
Interested in working with us?
To inquire about opportunities, send an email with a CV, and concise statements of your scientific interests and career interests. We value strong foundation, good work ethic, and interest in solving important problems with collaborative colleagues over past experience in our areas of focus.
If you are based at one of the three partner universities (UC Berkeley, UCSF, and Stanford), we have mechanisms for internships and long-term collaborations.